The basic considerations for critical appraisal of intervention studies are:
Are the results valid?
- Were participants randomized?
- Was randomization concealed?
- Were participants analyzed in the groups to which they were randomized?
- Were participants treatment and control group similar with respect to known prognostic factors?
- Were participants aware of group allocation?
- Were clinicians aware of group allocation?
- Were outcome assessors aware of group allocation?
- Was follow-up complete?
What are the results?
- How large was the treatment effect?
- How precise was the estimate of the treatment effect?
How can I apply the results?
- Were study participants similar to my own situation?
- Were all clinically important outcomes (harms and benefits) considered?
Based on Guyatt & Rennie, 2002