Good question! We have gone from a situation of having no information, to having too much information for some issues in public health.
I am assuming this is a question of effectiveness of some intervention.
Read only the methods section of the abstracts. As you read the abstracts, put the papers into piles using the categories listed below and then read the papers in the same order. If you have a high quality, recent systematic review, you can stop there. Likewise, if there is a no systematic review, but there is a good randomized trial, and the population in the study is similar to yours, you can stop there.
1. Systematic reviews.
2. randomized trials
3. two group (one group gets the intervention, one does not) with measurements before AND after
4. one group before/after
5. one group after only
6. case control
For future reference, you can limit your search in the above order, to prevent ending up with the piles of paper!
Donna