Situations where you need a comparison group are those when you are trying to determine if an intervention or program has made a difference i.e., was it effective? In that case the group that gets the new program or intervention is your “treatment group” and your “comparison group” could be the group that is receiving the “standard care” or usual program (which could be nothing).
If your question is about meaning, as may be the case in qualitative research, there may be no comparison. For example, why do female teens smoke cigarettes? Instead of PICO (Population, Intervention, Comparison and Outcome) , we use PS (Population and Situation) - the population (female teens), the situation (smoking cigarettes) in order to find relevant research.
Donna