Grey Matters: A Practical Tool for Searching Health-related Grey Literature

Canadian Agency for Drugs and Technologies in Health (2011). Grey Matters: A practical search tool for evidence-based medicine. Retrieved from Organization website:

Canadian En français


This practical search tool is designed for evidence-based medicine. Created by the Information Services team at the Canadian Agency for Drugs and Technologies (CADTH), this checklist aims to:

  • ensure retrieval of relevant government, evidence-based agency reports that may not be indexed in bibliographic databases
  • document the grey literature search process so that is transparent and reproducible
  • ensure a standard and systematic approach to searching grey literature

Steps for Using Method/Tool

The tool guides users through a list of resources organized by the following topics:

  • Health technology assessment agencies
  • Clinical practice guidelines
  • Drug and device regulatory approvals
  • Advisories and warnings
  • Drug class reviews
  • Clinical trials
  • Canadian drug formularies
  • Open access databases
  • Statistics
  • Miscellaneous

These summaries are written by the NCCMT to condense and to provide an overview of the resources listed in the Registry of Methods and Tools and to give suggestions for their use in a public health context. For more information on individual methods and tools included in the review, please consult the authors/developers of the original resources.

We have provided the resources and links as a convenience and for informational purposes only; they do not constitute an endorsement or an approval by McMaster University of any of the products, services or opinions of the external organizations, nor have the external organizations endorsed their resources and links as provided by McMaster University. McMaster University bears no responsibility for the accuracy, legality or content of the external sites.

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